Ming-Feng Tsai and Christopher Miller summarize our recent work as, “Chowdhury and colleagues report thermodynamics-inspired experiments that productively attack a long-lingering problem in sensory neurobiology: how certain ion channel proteins achieve the exquisite thermosensitivity that allows the neurons housing them—and us—to detect changes in temperature.” Read more from Tsai’s commentary in “Building a Temperature-Sensitive Ion Channel.”