Chanda Lab moves to Washington University in St. Louis!

Dr. Chanda has accepted an exciting offer to join the Department of Anesthesiology at Washington University School of Medicine in St. Louis! The lab will be moving in April 2020. See you in the Show-Me State!

New Paper online!

Our new paper on the NMR structural analysis of the isolated voltage-sensing domain from Shaker is now online!See it here!

Farewell Claudia!

The lab gathers with friends and family over delicious food and drinks to wish Claudia the best of luck on her next adventure!

DISC is Live!

We are excited to announce that our new single-molecule analysis software DISC is now available on GitHub! We have posted a pre-print of our manuscript describing this incredibly fast and accurate method on bioRxiv! Links: Download DISC here  Read our paper here

PNAS Paper Out Now!

See our new publication on the mechanism underlying the hyperpolarization activation of HCN channels in PNAS!

Welcome Willy and Jenna!

The Chanda lab is happy to welcome our new members! Dr. Willy Carrasquel-Ursulaez  joins as a postdoctoral researcher and Jenna Lin is a first year graduate student in the Biophysics Training Program.

Two New Undergrads in the Lab!

The Chanda lab welcomes our two new undergraduate researchers in the lab! Stephan is a senior undergraduate in biochemistry and Owen is a sophomore majoring in physics (and maybe mathematics, too). Both will be working with Ruohan and David on various aspects of the single-molecule projects in the lab.

New Paper: Molecular determinants of efficacy in the HCN channel family

New JGP paper now online! In this study, Dr. Claudia Alvarez-Baron and Dr. Vadim A. Klenchin explore what underlies the molecular basis for increased cAMP efficacy in HCN2 channels using a mutagenesis, electrophysiology, and kinetic modeling. See the paper here!

New Paper Online!

Our new publication in Nature Structural and Molecular Biology is now online!  This study was led by Dr. Ana I. Fernandez-Marino and aided by a  fruitful collaboration with Dr. Lucie Delemotte lab at KTH Royal Institute of Technology, Solna, Sweden.  See the paper here.

Welcome New Members!

The Chanda lab is excited to welcome two new additions to the group! Debanjan joins us a doctoral researcher and Nandinin as a research intern!

Welcome back Alex!

After a semester study in Paris, Alex, an undergrad in the lab, has suffered enough with the wine and happily came back for the fascinating science (and beer). Welcome back Alex, we miss you!

Nature paper now online!

Second collaboration between Ed Chapman’s lab and Chanda lab led by Huan and Debasis of Chapman lab gets to Nature. Yihao from Chanda lab helps with developing the single fusion pore recording. Fresh online, take a look!

Farewell Marcel!

It is bittersweet for the Chanda lab to say farewell to our  Dr. Marcel P. Goldschen-Ohm as he begins the next step in his career as an Assistant Professor of Neuroscience at the University of Texas-Austin! Marcel joined the Chanda lab in September of 2009 and has had many scientific accomplishments, specifically in the use of  single-molecule methods to probe ion channel gating. We wish […]

Welcome Rotators!

The Chanda lab is happy to welcome our first year rotation students Wu Lanxi (Biophysics Program) and Alex Duckworth (IPIB)!

Welcome Dr. Ruohan Zhang!

The Chanda lab is thrilled to welcome our newest post-doc, Ruohan Zhang! Ruohan comes from ASU where he did his PhD under Dr. Timoth Steimle using spectroscopic methods to study the rotational and vibrational structures of small metal-containing molecules in the gas phase. Ruohan joins David in being  jointly advised  between Baron and Randall Goldsmith and aims to […]

Farewell Alex!

The Chanda lab bids farewell to Alex as he begins his semester abroad in France. Safe travels!

Stanford’s rotation begins!

The Chanda lab welcomes a new summer rotation student, Stanford Mitchell. Stanford will be (officially) starting at UW-Madison this upcoming fall semester in the Molecular and Cellular Pharmacology program.

Congratulations John!

John has been awarded a Predoctoral Fellowship from UW’s Cardiovascular Research Center (CVRC). Congratulations!

Welcome Aindrila!

The Chanda welcomes our new summer student, Aindrila Saha! Aindrila is a student through the Khorna Program and will be working with Claudia in the lab to studying the gating mechanisms of HCN channels.

Congratulations Alex!

Our undergraduate researcher Alex Blair has been awarded the Hilldale Undergraduate Research Award! Way to go Alex!

Visit from Dr. Teresa Giraldez Fernandez!

Friend and fellow ion channel enthusiast Dr. Teresa Giraldez Fernandez from the Department of Biomedical Research Universidad de La Laguna visits Madison! In addition to giving a fantastic talk, she was treated to a day out ice fishing with the lab! See photos here!

Marcel honored as a Postdoctoral Reviewer for JGP

Marcel Goldschen-Ohm has definitely been busy! Among writing many of his own papers, he found the time review a number many as well for the  Journal of General Physiology- more so than any other postdoctoral reviewer!  Here, JGP Editor-in-Chief Sharona E. Gordono presents Marcel with an award for  Postdoctoral Reviewer for Reviewed the Most Manuscripts […]

BPS 2017!

The Chanda group attends the 61st Annual Biophysical Society Meeting in New Orleans, Louisiana!  Check out our gallery from the week in NOLA here!

New Student!

The Chanda group is pleased to welcome a new graduate student – Prasanth Kumar! Welcome!

Way to go Claudia!

Claudia is a proud recipient of the American Heart Association Postdoctoral Fellowship! Great job Claudia!!

eLIFE Paper Published!

Co-first authors Marcel and Dima publish their paper in eLIFE where they combine single-molecule binding dynamics and a novel crystal structure to understand how cAMP binds to monomeric cyclic nucleotide binding domains of HCN2 channels. This also marks the first paper for both John and David from the lab! Congratulations all!

Farewell party for Ana!

We bid farewell to our postdoc Ana over drinks and food at the Great Dane Pub! Ana will be starting a second postdoctoral fellowship in the lab of Kenton Swartz at NIH. We will miss you Ana and best of luck!

Farewells and Introductions

We are sad to see our undergraduate lab technican Zach leave but are happy to welcome his replacement, Natalie! Natalie is a first year undergraduate student in pursuit of biomedical engineering. Welcome Natalie!

Summer BBQ

Summer BBQ at Baron’s house with friends and colleagues from UW.

The lab sets sail!

The Chanda lab enjoys a day sailing on Lake Mendota captained by our very own undergraduate Alex!

Lab Outing!

The Chanda lab visits Union South for a day of cake, beer, and bowling!

Collaborative work leads to NSMB cover article!

In collaboration with Ed Chapman’s lab here at UW-Madison, Marcel helped to demonstrate that exocytic fusion pores are composed of both lipids and proteins. This article was featured as the cover of Nature Structural and Molecular Biology for the December 2015 issue!

Congratulations Dr. Kevin Oelstrom

Kevin has successfully defended his PhD thesis titled “Understanding the Gating Mechanisms of Voltage-dependent Sodium and Potassium Channels”. Kevin will soon be starting his new position at Ceullar Dynamics International with former Chanda lab member, Brian. Congratulations Kevin! You will be greatly missed!

New Student!

David White has joined the lab from the Neuroscience Training Program and will be jointly-advised by Baron and Randall Goldsmith from the Department of Chemistry. Welcome David!

New Undergraduate Researcher

Alex Blair joins the lab as an undergraduate researcher! Alex is a sophmore majoring in Biology.

NSMB News & Views from Marcel

Marcel’s commetary “How to open a proton-pore more than S4” has been published in Nature Structural and Molecular Biology

Welcome Hongbo!

Hongbo Chen joins the Chanda lab as a co-advised student with Katherine Henzler-Wildmann. Hongbo will be using NMR to tease apart ion channel structure-function. Welcome!

New Graduate Students!

The Chanda lab is happy to welcome two new graduate students from the Biophysics Graduate Program- John Cowgill and Yihao Jiang!

Lab Outing

The Chanda lab goes laser tagging!!

Welcome Claudia!

Dr. Claudia P. Alvarez-Baron joins the group as a postdoctoral fellow! Welcome!

Cracking Tough Nuts

Ming-Feng Tsai and Christopher Miller summarize our recent work as, “Chowdhury and colleagues report thermodynamics-inspired experiments that productively attack a long-lingering problem in sensory neurobiology: how certain ion channel proteins achieve the exquisite thermosensitivity that allows the neurons housing them—and us—to detect changes in temperature.”  Read more from Tsai’s commentary in “Building a Temperature-Sensitive Ion Channel.”