2021

White, D.S., Chowdhury, S., Idikuda, V., Zhang, R., Retterer, S. T., Goldsmith, R. H., Chanda, B. “cAMP binding to closed pacemaker ion channels is non-cooperative” Nature, June 30, 2021, DOI: 10.1038/s41586-021-03686-x Article Link

Cowgill, J., Chanda, B. “Mapping Electromechanical Coupling Pathways in Voltage-Gated Ion Channels: Challenges and the Way Forward” Journal of Molecular Biology, June 15, 2021, DOI: 10.1016/j.jmb.2021.167104 Article Link

Chen, H., Deng, J., Cui, Q., Chanda, B., Henzler-Wildman, K. “Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K+ channel” Proceedings of the National Academy of Sciences (USA), April 6, 2021, DOI: 10.1073/pnas.2017280118 Article Link

2020

Jiang, Y., Idikuda, V., Chowdhury, S., Chanda, B. “Activation of the archaeal ion channel MthK is exquisitely regulated by temperature” eLife, December 4, 2020, DOI: 10.7554/eLife.59055 Article Link

Carrasquel-Ursulaez, W., Reeves, R.D., Dehghany, M., Jones, C., Schomaker, J.M., Chanda, B. “Re-evaluation of the mechanism of cytotoxicity of dialkylated lariat ether compounds” Royal Society of Chemistry Advances, November 5, 2020, DOI: 10.1039/d0ra08494h Article Link

White, D.S., Goldschen-Ohm, M.P., Goldsmith, R.H., Chanda, B. “Top-down machine learning approach for high-throughput single-molecule analysis” eLife, April 8, 2020, DOI: 10.7554/eLife.53357 Article Link

2019

Kasimova, M.A., Tewari, D., Cowgill, J.B., Ursuleaz, W.C., Lin, J.L., Delemotte, L. and Chanda, B. “Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating” eLife, November 27, 2019, DOI: 10.7554/eLife.53400 Article Link

Cowgill, J.B., Chanda, B. “The contribution of voltage clamp fluorometry to the understanding of channel and transporter mechanisms.” Journal of General Physiology, August 20, 2019, DOI: 10.1085/jgp.201912372 Article Link

Chen, H., Pan, J., Gandhi, D.M., Dockendorff,C., Cui, Q., Chanda, B., Henzler-Wildman,K.A. “NMR structural analysis of isolated Shaker voltage-sensing domain in LPPG micelles”, Biophysical Journal, June 25th, 2019, DOI: 10.1016/j.bpj.2019.0.20 Article Link

White, D.S., Goldschen-Ohm, M.P., Goldsmith, R.H., & Chanda, B. “High-Throughput Single-Molecule Analysis via Divisive Segmentation and Clustering”. bioRxiv, 603761 (2019).DOI: 10.1101/603761 Article Link

Chowdhury, S., Chanda, B. “Sodium channels caught in the act”. Science, March 22, 2019, 363 (6433) 1278-1279, DOI: 10.1126/science.aaw8645. Article Link

Cowgill, J., Klenchin, V.A., Alvarez-Baron, C.P., Tewari, D., Blair, A., Chanda, B.; “Bipolar switching by HCN voltage sensor underlies hyperpolarization activation”, Proceedings of the National Academy of Sciences (USA), January 2018, 

2018

Alvarez-Baron, C.P., Klenchin, V.A., Chanda, B.;  “Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family”, 

Fernández-Mariño, A.I., Harpole, T.J., Oelstrom, K., Delemotte, L., and Chanda, B.;  “Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel”, Nature Structural & Molecular Biology, 25, 320-326. DOI: 10.1038/s41594-018-0047-3. Article Link.

Bao, H., Das, D., Courtney, N.A., Jiang, Y., Briguglio, J.S., Lou, X., Roston, D., Cui, Q., Chanda, B., and Chapman, E.R.; “Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties”, Nature 554, 260. DOI: 10.1038/nature25481. Article Link.

2017

Goldschen-Ohm, M.P., Chanda, B.; “SnapShot: Channel Gating Mechanisms”, Cell, Volume 170, Issue 3, 2017, Pages 594-594.e1, ISSN 0092-8674, http://dx.doi.org/10.1016/j.cell.2017.07.019. Article Link.

Zhao, Y., Goldschen-Ohm, M.P., Morais-Cabral, J.H., Chanda, B., and Robertson, G.A.; “The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation”. Journal of General Physiology DOI:10.1085/jgp.201611701. Article Link.

Goldschen-Ohm, M.P., White, D., Klenchin, V., Chanda. B., and Goldsmith, R.; “Observing single molecule dynamics at millimolar concentrations”, Angew. Chem. Int. Ed. DOI:10.1002/anie.201612050. Article Link.

2016

Ahern, C.A., Payandeh, J.P., Bosmans, F., and Chanda, B.; “The hitchhiker’s guide to the voltage-gated sodium channel galaxy”,  Journal of General Physiology 147 (1): 1-24. Article Link.

Oelstrom, K., Chanda, B.; “Congruent pattern of accessibility identifies minimal pore gate in a nonsymmetric voltage-gated sodium channel”, Nature Communications DOI:10.1038/ncomms11608. Article Link.

Goldschen-Ohm MP, Klenchin VA, White DS, Cowgill JB, Cui Q, Goldsmith RH, Chanda B.;  “Structure and dynamics underlying elementary ligand binding events in human pacemaking channels”, Elife. 2016 Nov 18;5PubMed PMID: 27858593; PubMed Central PMCID: PMC5115869Article Link.

2015

Bao, H., Goldschen-Ohm, M., Jeggle, P., Chanda, B., Edwardson, J.M., Chapman, E.R.;  “Exocytotic fusion pore are composed of both lipids and proteins”, Nature Structural and Molecular Biology 23, 67-73  | doi:10.1038/nsmb3141. Article Link

  • Highlighted in “The mystery of the fusion pore” by Satyan Sharma and Manfred Lindau, (ibid. Pgs. 5-6). Article Link

2014

Chowdhury, S., Haehnal, B.M., and Chanda, B.; “Interfacial gating triad is crucial for electromechanical transduction in voltage-activated potassium channels”, Journal of General Physiology 144:457-467. Article Link

Chowdhury, S., Haehnal, B.M., and Chanda, B.; “A self-consistent approach for determining pairwise interactions that underlie channel activation”, Journal of General Physiology 144: 441-455. Article Link

Chowdhury, S., Jarecki, B.W., Chanda, B.; ” A Molecular framework for temperature-dependent gating of ion channels”,  Cell 158, 1148-1158. Article Link

  • Highlighted in “Building a temperature-sensitive ion channel” by Ming-Feng Tsai and Christopher Miller, (ibid. Pgs. 977-979). Article Link
  • A video abstract was featured as PaperFlick in the online issue. Video Link.

Oelstrom K.M., Goldschen-Ohm, M.P., Holmgren, M., Chanda, B., “Evolutionarily conserved intracellular gate of voltage-gated sodium channels”, Nature Communications DOI:10.1038/ncomms4420. Article Link

Jarecki, B.W., Zheng, S.L., Zhang, L., Li, X., Zhou, X., Cui, Q., Tang, W., Chanda, B.,  “Tethered spectroscopic probes estimate dynamic distances with sub-nanometer resolution in voltage-dependent potassium channels”, Biophysical Journal 105(12) 2724-2732. Article Link

  • Featured in research highlights section in Nature Chemical Biology February 2014 (pg. 169). Article Link
  • Highlighted in “New rule(r)s for FRET”  by Frank Bosmans, (ibid. Pgs. 2619-2620). Article Link

2013

Capes, D.L., Goldschen-Ohm, M.P., Arcisio-Miranda, M. Bezanilla, F., Chanda, B., “Domain IV voltage-sensor is both sufficient and rate-limiting for fast inactivation in sodium channels. Journal of General Physiology 142 (2), 101-112. Article Link

  • Highlighted in “What activates inactivation?”  by Christopher Ahern, (ibid. Pgs. 97-100). Article Link

Goldschen-Ohm, M.P., Capes, D.L., Oelstrom, K., Chanda, B., “Multiple pore conformations driven by asynchronous movements of voltage-sensors in a eukaryotic sodium channel”, Nature Communications 4:1350. doi: 10.1038/ncomms2356. Article Link

Jarecki, B.W., Makino, S., Beebe, E., Fox, B., Chanda, B., “Function of Shaker potassium channels produced by cell-free translation upon injection into Xenopus oocytes. Scientific Reports 3:1040. doi: 10.1038/srep01040. Article Link

Chowdhury, S., Chanda, B., “Free energy relationships in ion channels activated by voltage and ligand”, Journal of General Physiology. 141(1): 11-28. Article Link

  • Highlighted in “No model in mind: A model-free approach for studying ion channel gating” by Ofer Yifrach (ibid. Pgs. 3-9). Article Link

2012

Capes, D., Arcisio-Miranda, M., Jarecki, B.W., French, R., Chanda, B., “Gating transitions in the selectivity filter region of a sodium channel are coupled to domain IV voltage-sensor”,  Proceedings of the National Academy of Sciences (USA) 109(7): 2648-53. Article Link

  • Highlighted in “Enhancement of closed-state inactivation by neutralization of S4 arginines in domain IV of a sodium channel” by Tzur Paldi (Frontiers in Pharmacology (2012) doi:10.3389/fphar.2012.00143 ) Article Link

Chowdhury, S., Chanda, B., “Estimating the voltage-dependent free energy change of ion channels using the median voltage of activation”, Journal of General Physiology 139 (1): 3-17. Article Link

  • Highlighted in “Model-free energy for voltage-gated ion channels” by Christopher Miller (ibid. Pgs 1-2). Article Link
  • Also highlighted in “Taking a thermodynamic approach: A conversation with Baron Chanda” by Elizabeth Adler (Journal of General Physiology vol. 144, no.2, Pg.127) Audio/transcript can be found here or here.

2010

Chowdhury, S., Chanda, B., “Deconstructing thermodynamic parameters from site-specific observables in a coupled system”, Proceedings of the National Academy of Sciences (USA)  107(44), 18856-18861. Article Link

Arcisio-Miranda, M., Muroi, Y., Chowdhury, S., Chanda, B., “Molecular basis of allosteric modification of voltage-dependent gating by local anesthetics”, Journal of General Physiology 136(5), 541-554. Article Link

Wang, D., Zhang, Z., Chanda, B., and Jackson, M. “Improved probes for hybrid voltage sensor imaging”, Biophysical Journal 99, 2355-2366. Article Link

Muroi, Y., Arcisio-Miranda, M., Chowdhury, S., Chanda, B., “Molecular determinants of coupling between the domain III voltage-sensor and pore of a sodium channel”, Nature Structural and Molecular Biology 17, 230-237. Article Link

2009

Muroi, Y., Chanda, B., “Local anesthetics disrupt energetic coupling between voltage-sensors of the sodium channel”, Journal of General Physiology 133, 1-15. Article Link

2008

Campos, F., Chanda B., Baeiro, P., and Bezanilla, F. “α-scorpion toxin impairs a conformational change that leads to fast inactivation of the sodium channels”, Journal of General Physiology 132, 251-62. Article Link

Kumari, S., Borroni, V., Chaudhary, A., Chanda, B., Massol, R., Mayor, S., and Barrantes, F.J. “The nicotinic acetylcholine receptor is internalized via a rac-dependent, dynamin-independent endocytic pathway”, Journal of Cell Biology 181, 1179-1193. Article Link

2007

Campos, F., Chanda, B., Baeiro, P., and Bezanilla, F., “b-scorpion toxin modifies gating transitions in all four voltage-sensors of the sodium channel”, Journal of General Physiology 130, 257-268. Article Link

Campos, F., Chanda, B., Roux, B. and Bezanillla, F., “Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 in the closed state of the Shaker K channel”,  Proceedings of the National Academy of Sciences (USA) 104(19), 7904-7909. Article Link

2006

Ben-Chaim, Y., Chanda, B., Bezanilla, F., Dascal, N., Parnas, I. and Parnas, H., “Movement of “gating charge” is coupled to ligand binding in a G-protein coupled receptor”,  Nature 444 (7115), 106-109. Article Link

  • Featured in a commentary “Voltage sparks GPCR” by Peter Stanfield. Nature cell Biology 8;1323-1325 (2006). Article Link