Baron Chanda, Ph.D.
Dr. Baron Chanda’s primary research interest is to understand the mechanisms of electrical signaling by membrane proteins such as ion channels. He graduated with a Bachelors degree in Biochemistry from the University of Delhi and a Masters degree in Biotechnology (Biophysics specialization) from the University of Pune, India. He obtained his Ph.D. at the National Center for Biological Sciences in India where he gained expertise in membrane protein biochemistry, fluorescence spectroscopy, and basic electrophysiology. In 2000, he moved to the University of California, Los Angeles to conduct postdoctoral research with Dr. Francisco Bezanilla. During this time, he did foundational work on mechanisms of gating of sodium and potassium channels using the newly developed voltage-clamp fluorometry. In the fall of 2006, he joined the Department of Physiology (now Neuroscience) at the University of Wisconsin-Madison as an Assistant Professor and was promoted to Associate Professor in 2012. In 2015, he was jointly appointed as a professor in the Department of Biomolecular Chemistry. As of late spring 2020, he joined Washington University School of Medicine as a Professor of Anesthesiology and has secondary appointments in the Department of Biochemistry and the Department of Neuroscience. While his scientific approach is rooted in reductionism, Chanda’s long-term interest is to gain a comprehensive understanding of ion channel function in a physiological context. Throughout his scientific career, he has also been actively involved in either developing or adopting new technologies to study mechanistic underpinnings of ion channel function.
bchanda (at) wustl.edu | 314-273-6811 | Twitter: @ChandaLab06
harter (at) wustl.edu
Yongchang Chang, M.D., Ph.D.
Yongchang received his Ph.D. in Physiology and Biophysics from the University of Alabama at Birmingham in 1998. He studied structure-function relationship of the pentameric ligand-gated ion channels for many years before joining Dr. Chanda’s lab in 2020 as a senior scientist. His current main project is to optimize conditions to generate large amounts of stable proteins for spHCN (HCN from sea urchin) for structural determination by cryo-EM. He is also involved in projects for chimera design and construction between different subfamily members for studying the gating mechanisms of HCN.
yongchang (at) wustl.edu
Ruohan Zhang, Ph.D.
Ruohan graduated from USTC with a Bachelor’s degree in the Department of Chemical Physics in 2011, and then he received his Ph.D. degree from the Department of Chemistry & Biochemistry of ASU in 2017. Ruohan used to be a traditional spectroscopic person studying the rotational and vibrational structures of small metal-containing molecules in the gas phase in Dr. Timothy Steimle’s group. However, Ruohan has recently become motivated to expand his knowledge into biochemistry and begin applying spectroscopic techniques to study large protein molecules. This drove him to become a joint post-doc in labs of Dr. Baron Chanda and Dr. Randall Goldsmith (UW-Madison Chemistry Department) with research interests on using single-molecule fluorescence microscopy to study the ion channel activities.
ruohan.zhang (at) wisc.edu
Debanjan Tewari, Ph.D.
Debanjan was awarded a Master’s degree in Biotechnology from Pondicherry University, India in 2009 and completed his doctoral research at the Indian Institute of Technology, Madras, India. His thesis primarily focused on the modulation of Voltage-Dependent Anion Channel (VDAC) by small anti-cancerous compounds. Following his doctoral degree in 2016, he joined the University of Montreal as a post-doctoral fellow where he worked on Voltage Clamp Fluorometry (VCF) as well as Bilayer Lipid Membrane. Since February 2018, Debanjan is working in Baron’s lab as a post-doctoral fellow, wherein his broad domain is to study different ion channels. During his free time, he enjoys wild-life and bird photography.
tewari (at) wustl.edu
Willy Carrasquel-Ursuleaz, Ph.D.
Willy graduated from the Central University of Venezuela with a Bachelor’s degree in Biology. He received a Ph.D. in Neuroscience from the Interdisciplinary Center for Neuroscience of Valparaíso (University of Valparaíso, Chile). During his PhD, Willy studied the biophysics of the BK channels and its interaction with accessory subunit γ1 in the Latorre lab. Willy joined the Chanda lab as a postdoc in the 2018 fall. His primary research interest is to overcome the current limitations of optogenetic techniques and develop an all-optical electrophysiology that is minimally invasive. In addition, he is exploring the voltage sensing mechanism of the HCN channels.
carrasquel (at) wustl.edu
Vinay Idikuda, Ph.D.
Vinay graduated from Osmania University with a Bachelor’s degree in Pharmacy in 2010. He received his PhD in Neuroscience from Virginia Commonwealth University in 2018. During his PhD, he studied ligand binding in HCN channels using patch clamp fluorometry in Dr. Lei Zhou’s lab. Vinay joined the Chanda lab in 2019 to further his interests in ion channels and membrane proteins. Currently, he is investigating the temperature sensitivity in calcium activated potassium channels. Outside the lab, Vinay enjoys hiking, playing badminton, and tennis.
idikuda (at) wustl.edu
John Cowgill, Ph.D.
John graduated from UW-Madison with a Bachelor’s degree in Biochemistry in 2010. He received a Masters in Biochemistry from ASU in 2012 studying the biophysics of Type-I photosynthetic reaction centers in Dr. Kevin Redding’s lab. In Fall 2014, John joined Dr. Chanda’s lab and received his PhD in Biophysics from UW-Madison in Summer 2020. His primary research interests include examining the different mechanisms of coupling sensing domains (temperature, voltage, and ligand) to pore domains in various voltage gated channels. He uses a combination of sequence and structural analysis to guide experimental design. Outside the lab, John likes playing ultimate frisbee, fishing, and taking his dog to the park.
john.c (at) wustl.edu
Verena Burtscher, Ph.D.
bverena (at) wustl.edu
Jenna graduated from the University of Missouri-Columbia with a B.S. in Biological Engineering and a minor in Biological Sciences in Spring 2018. At Mizzou, she was in Drs. Lorin and Mirela Milescu labs where she developed a great interest in ion channels, electrophysiology, and neuroscience. In Fall 2018, she joined the Biophysics Graduate Program at UW-Madison and Dr. Chanda’s lab. When the Chanda lab moved to WashU, Jenna moved with the lab and joined the Biochemistry, Biophysics & Structural Biology Program at WashU in Fall 2020. She enjoys taking an interdisciplinary approach to problems and combining science and engineering. Currently, Jenna is interested in understanding the relationship between the architecture and function of ion channels via evolutionary approaches such as ancestral sequence reconstruction. Outside of the lab, Jenna enjoys playing piano, hiking, and cooking.
jllin (at) wustl.edu