An introductory video on Linkage analysis by our collaborator, Dan Sigg. This video abstract accompanied two back to back articles in the Journal of General Physiology on the application of Linkage analysis to probe molecular basis of allosteric interactions.
Chowdhury, S. and Chanda, B. (2013) Free-energy relationships in ion channels activated by voltage and ligand.Journal of General Physiology 141(1): 11–28.
Sigg, D (2013) A linkage analysis toolkit for studying allosteric networks in ion channels. Journal of General Physiology 141(1): 29–60.